Table 4.
Univariable Logistic Regression Analysis of Imaging, Procedural and Cytological Characteristics Associated With Success run of NGS Using EBUS-TBNA Samples
| DNA NGS (N=226) | RNA NGS (N=106) | |||
|---|---|---|---|---|
| Success rate, % (No. of Success Run / total No.) | OR (95% CI) | Success rate, % (No. of Success Run / total No.) | OR (95% CI) | |
| CT short-axis diameter, mm | ||||
| >5 to <10 | 92.0% (46/50) | 1.3 (0.3 – 4.7) | 90.5% (19/21) | 1.4 (0.2 – 9.3) |
| >10 to <20 | 93.6% (88/94) | 1.4 (0.3–6.0) | 93.2% (41/44) | 1.1 (0.2 – 6.9) |
| >20 | 94.3% (66/70) | 90.9% (30/33) | ||
| FDG avidity, SUV | ||||
| >2.5 to <5 | 84.6% (22/26) | 2.0 (0.5 – 7.7) | 92.3% (12/13) | 0.8 (0.1 – 8.5) |
| >5 to <10 | 91.7% (66/72) | 6.2 (0.6 – 59.0) | 90.6% (29/32) | / |
| >10 to <15 | 97.1% (34/35) | 2 (0.3 – 12.1) | 100.0% (17/17) | 0.5 (0.0 – 5.8) |
| > 15 | 91.7% (22/24) | 84.6% (11/13) | ||
| Tissue source | ||||
| Primary tumor+N1 | 86.7% (52/60) | 3.5 (1.2 – 10.0) | 93.3% (28/30) | 0.7 (0.1 – 3.4) |
| N2+N3 | 95.7% (157/164) | 90.3% (65/72) | ||
| Number of passes, n | ||||
| <3 | 94.3% (116/123) | 0.8 (0.3 – 2.3) | 87.7% (50/57) | 3.2 (0.6 – 16.3) |
| >3 | 92.9% (92/99) | 95.8% (46/48) | ||
| Tumor cellularity, % | ||||
| 10–25 | 88.2% (75/85) | 3.4 (1.1 – 10.4) | 86.4% (38/44) | 3.1 (0.7 – 13.2) |
| >25 | 96.3% (129/134) | 95.2% (59/62) | ||
Abbreviations: 95% CI = 95% confidence interval; EBUS-TBNA = endobronchial ultrasound-guided transbronchial needle aspiration; FDG = fluorodeoxyglucose; NGS = next generation sequencing; OR = Odds Ratio; SUVmax = maximum standardized uptake value.