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. Author manuscript; available in PMC: 2023 Nov 22.
Published in final edited form as: Lancet Child Adolesc Health. 2022 Sep;6(9):643–653. doi: 10.1016/S2352-4642(22)00192-4

Figure 1: Prenatal stem-cell therapy.

Figure 1:

IUTX has been performed in several disorders using different types and sources of cells. Successful therapeutic effect might depend upon the gestational age, the route of administration, host cell competition, niche receptivity, and fetal and maternal immunity (such as the presence of maternal antibodies crossing the placenta, depicted as the antibodies on the mother and fetus). IUTX=in-utero stem-cell transplantation. HSC=haematopoietic stem and progenitor cell. MSC=mesenchymal stem and progenitor cell. FLSC=fetal liver stem cell.