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. Author manuscript; available in PMC: 2023 Nov 22.
Published in final edited form as: Tetrahedron. 2022 Oct 5;126:133071. doi: 10.1016/j.tet.2022.133071

Fig. 4.

Fig. 4.

(a) Scope of peptide cyclization for the synthesis of strained head-to-tail cyclic tetrapeptides. Reaction conditions: 3.3 mM of peptides 1b-1l in H2O:DMF were treated with DIEA (21 equiv.) and reaction mixtures were left for stirring at 60 °C for 16 h and analysis by HPLC to determine the (%) conversion of cyclic tetrapeptides 2b-2l. (b) Novel biCyClick peptide structure 2m from linear pentapeptide 1m without the turn inducer.