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. 2023 Nov 15;623(7988):772–781. doi: 10.1038/s41586-023-06548-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Distribution of lochNESS in each sub-trajectory of the mutants in the FVB background strain, all of which are TAD boundary KOs. Dashed boxes in the sixth column highlight the most deviated epithelial sub-trajectories in the Tbx3 TAD Boundary KO mutant. b, Row-normalised heatmap showing the average euclidean distance between lochNESS and lochNESS under permutation in each sub-trajectory for the same mutants shown in panel a, centred and scaled by row. Dashed boxes in the sixth column again highlight the most deviated epithelial sub-trajectories in the Tbx3 TAD Boundary KO mutant. c, UMAP showing co-embedding of Tbx3 TAD Boundary KO and pooled wildtype cells in the pre−epidermal keratinocyte, epidermis, branchial arch, and lung epithelial sub-trajectories, coloured by lochNESS (top left) [with blown up insets showing lochNESS in lung epithelial (bottom left) and epidermis (bottom right) sub-trajectories], or by sub-trajectory identity (right). LochNESS colour scale is centred at the median of lochNESS. d, same as in panel c, but coloured by expression of selected mutant related genes and marker genes.