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. 2023 Nov 8;623(7988):820–827. doi: 10.1038/s41586-023-06706-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 17 — a. Tumor regression in individual mice in vivo treated with PC-CARs (n = 6; source data provided in Supplementary Table 3). b. COG-564x tumors collected from 302LH PC-CAR-treated mice collected at when mice reached tumor burden on day 11 (left) and endpoint of study on day 38 (right). Though tumors are detectable at endpoint, H&E and PHOX2B staining of 302LH PC-CAR-treated tumors reveals entirely necrotic tissue by endpoint of the study. Single available tumor collected from mouse reaching tumor burden for D11 and single endpoint tumor in one experiment collected for immunohistochemistry shown.