Fig. 3. Fragmentation sites of the fibril proteins.

a Red circles: location of the fragmentation sites in the sequence of the fibril proteins. Yellow circle: mutational sites, continuous lines: fibril core; dotted lines: TTR segments not seen in the 3D map. b Location of the fragmentation sites in the 3D structure as represented by a ribbon diagram of the molecular model (continuous line), which is superimposed with a section through the 3D map (gray). The yellow circle indicate the mutational sites. The dotted lines represent the unresolved part of TTR, drawn in arbitrary conformation. The figure is based the unambiguously assigned TTR fragments as outlined in Supplementary Tables 3–5.