Table 3.

Incidence of adverse events after bronchoscopy.

Adverse events after bronchoscopy	Total (N = 100)	Midazolam (n = 51)	Remimazolam (n = 49)	P-value
Bradycardia	0 (0.0)	0 (0.0)	0 (0.0)
Tachycardia	4 (4.0)	2 (3.9)	2 (4.1)	1.000
Vomiting	0 (0.0)	0 (0.0)	0 (0.0)
Hypotension	2 (2.0)	1 (2.0)	1 (2.0)	1.000
Hypoxemia	2 (2.0)	1 (2.0)	1 (2.0)	1.000
Use of Antidote	10 (10.0)	8 (15.7)	2 (4.1)	0.092
Pneumonia	0 (0.0)	0 (0.0)	0 (0.0)
Pneumothorax	0 (0.0)	0 (0.0)	0 (0.0)
ARDS or ICU admission	1 (1.0)	1 (2.0)*	0 (0.0)	1.000

Data are presented as numbers (%).

ARDS acute respiratory distress syndrome, ICU intensive care unit.

*One patient (male, 69 years) in the midazolam group developed severe ARDS 24 h after the procedure. He was admitted with anorexia, cough, night sweating, and general weakness for 20 days. Chest computed tomography scan showed multifocal consolidations, and bronchoscopic saline washing was performed. He died 53 h after bronchoscopy owing to aggravated ARDS and multi-organ failure.