Skip to main content
. 2023 Nov 22;14(11):759. doi: 10.1038/s41419-023-06280-3

Fig. 1. Podoplanin is overexpressed in OSCC stroma and is correlated with poor prognosis.

Fig. 1

A Gene expression levels of PDPN in normal and OSCC stroma (n = 32) using laser-captured microdissection and qRT-PCR. Student’s t test for two-group comparison: **P <0.01. B Immunohistochemical staining of PDPN and α-SMA in OSCC tissues and adjacent normal tissues (n = 40). Scale bar, 200 µm. C The proportion of different extent of PDPN and α-SMA expression in OSCC stroma. D Immunofluorescence staining identification of CAFs using vimentin, PDPN, cytokeratin 14, and α-SMA. Bar for morphological observation, 20 µm; bar for immunofluorescence staining, 100 µm. E Gene expression levels of activated fibroblasts markers in NFs and CAFs. Student’s t test for two-group comparison: **P <0.01. F Kaplan–Meier plots of PDPN expression in 40 cases of OSCC patients. Overall survival rate was performed by log-rank test. log-rank test: P < 0.05.