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. 2023 Nov 22;14(11):759. doi: 10.1038/s41419-023-06280-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Transmission electron microscopy (TEM) showing exosomes isolated from PDPN-transfected CAFs conditioned medium. Scale bar, 100 nm. B The size distribution exosomes from PDPN-transfected CAFs examined by nanoparticle tracking analysis (NTA). C Western blot analysis of exosomes from PDPN-transfected CAFs. D OSCC cells absorbed PKH26-labeled exosomes (red) secreted by PDPN-transfected CAFs. Fluorescence microscopy was used to detect the phalloidin (green) and PKH26-labeled exosomes (red) fluorescent signals in OSCC cells. Bar, 100 μm. E, F Volcano plot (E) and heatmap diagram (F) showing differentially expressed lncRNAs between CAF/Control and CAF/sh-PDPN derived exosomes. G The expression of the selected lncRNAs in the CAF/Control and CAF/sh-PDPN derived exosomes was validated by qRT-PCR. H The expression of FTX in OSCC cells treated with PDPN-transfected CAFs derived exosomes was validated by qRT-PCR. Student’s t test for two-group comparison: **P < 0.01.