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. 2023 Nov 22;13:20495. doi: 10.1038/s41598-023-47222-5

Figure 1.

Figure 1

Schematic illustration of conditional Kiss1 knockout (KO) in κ-opioid receptor (KOR)-positive or all kisspeptin neurons in female rats. (a) Generation of rats with conditionally deleted Kiss1 in KOR-positive anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) kisspeptin neurons (Kiss1-floxed/Oprk1-Cre rats) by crossing Oprk1-Cre rats with Kiss1-floxed rats. (b) Generation of rats with conditionally deleted Kiss1 in all kisspeptin neurons (Kiss1-floxed/Kiss1-Cre rats) by crossing Kiss1-Cre rats with Kiss1-floxed rats.