Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 22;13:20495. doi: 10.1038/s41598-023-47222-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Treatment with a proestrous level of E2 (high E2) induced a surge-like increase in LH in OVX Kiss1-floxed/Oprk1-Cre rats, but the LH surge was attenuated by the conditional Kiss1 deletion in cells expressing or having expressed Oprk1. (a) Mean plasma LH profiles of OVX + high E2 Kiss1-floxed/Oprk1-Cre rats and Cre(−)/Kiss1-floxed control rats. The area under the curve of the afternoon LH surge (b), the peak levels of the LH surge (c), the baseline LH levels (d), and the ratios of the peak levels of the LH surge to the baseline LH levels (e) in OVX + high E2 Kiss1-floxed/Oprk1-Cre rats and Cre(−)/Kiss1-floxed control rats. Values are the means ± SEM. Numbers in each column indicate the number of animals used. An asterisk indicates a statistically significant difference (p < 0.05) between the groups based on Student’s t-test.