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Proposed model of the interplay between H2A.Z.1 and HP1α/β in PCH. (A) In contrast to the rest of the genome, H2A.Z.1 and HP1α show an antagonistic interplay in PCH, where it interacts preferentially with HP1β. (B) We suggest that the role of HP1α as an organizer of PCH compartmentalization regulates the deposition of H2A.Z.1 through HP1β. In turn H2A.Z.1 controls the establishment of heterochromatin hallmarks such as H4K20me3, H3K9me3 and H3K27me3 through an undefined mechanism.
