Figure S4. Dynamic behavior of FEN1-YFP upon local DNA damage induction by laser irradiation after inhibition of DNA damage signaling.

Recruitment curve of FEN1-YFP onto the locally damaged DNA (LD) by laser irradiation in untreated primary dermal fibroblast isolated from the Fen1-YFP mouse model (green curve), treated with the ATM inhibitor Ku55993 (black curve), treated with the ATM/ATR inhibitor VE821 (violet curve), and treated with both Ku55993 and VE821 (yellow curve).