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. 2023 Nov 22;7(2):e202302279. doi: 10.26508/lsa.202302279

Figure S5. The reduction of DNA repair activity in differentiated FEN1-YFP myonuclei.

Figure S5.

(A) The steady-state level of FEN1-YFP represents the mean of YFP intensity before the locally damaging DNA (LD) by laser irradiation in different cellular types isolated from the Fen1-YFP mouse model: myoblasts (MB) and myotubes (MT); primary dermal fibroblast isolated (F) and the same fibroblasts fused with PEG (FF). Error bars represent the SEM obtained from at least 15 nuclei, significance by t test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. (B) The level of FEN1-YFP recruited to the LD by laser irradiation represents the mean of YFP maximum intensity after DNA damage induction in different cellular types isolated from the Fen1-YFP mouse model: MB and MT; F and FF. Error bars represent the SEM obtained from at least 15 nuclei, significance by t test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.