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. 2023 Nov 9;17:1294420. doi: 10.3389/fncel.2023.1294420

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Copyright © 2023 Neto, Fernandes and Barateiro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of obesity on neurodegenerative diseases. This figure illustrates the shared and distinctive effects of obesity on multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD), providing insights into the common pathways and disease-specific mechanisms contributing to neurodegeneration in these conditions. 3xTgAD, Triple-transgenic model of Alzheimer’s disease; Aβ, Amyloid-beta; APP, amyloid-beta precursor protein; BBB, blood brain barrier; DMTs, disease modifying treatments; CNS, Central Nervous System; FA, fatty acid; LepR, leptin receptor; PPAR, peroxisome proliferator-activated receptor; SN, substantia nigra, TH, tyrosine hydroxylase; VTA, ventral tegmental area.