Sequence similarity networks of SFP aldolases at alignment score 90 (i.e., ≥ 52.5% similarity).A, the large cluster contains 1000 class I SFP aldolases and the small cluster contains 102 class II SFP aldolases. B, SSN colored based on phyla of bacteria containing SFP aldolase, (C) SSN colored based on genetic context of SFP aldolase gene within proposed sulfo-EMP1, sulfo-EMP2, or hybrid sulfo-EMP1/2 gene clusters, (D) SSN colored based on presence of SLA reductase (YihU) or SLA dehydrogenase (SlaB/GabD) in the proposed gene cluster. SFP, sulfofructose-1-phosphate; SLA, sulfolactaldehyde; SSN, sequence similarity network; sulfo-EMP, sulfoglycolytic Embden–Meyerhof–Parnas.