Table 2.
ddPCR based CNV measurement: comparison tissue DNA versus ctDNA.
| tissue gDNA Baseline |
ctDNA first sample |
|||||||
|---|---|---|---|---|---|---|---|---|
| pat | Patho HER2 status (TOGA) | Mean tCNV∗1 | tCNV Ref_Chr.17 | gDNA HER2 status | T0 vs B0 (weeks) | Mean pCNV∗1 | pCNV Ref_Chr.17 | ctDNA HER2 status |
| GC11 | Her2 pos | 1.75 ± 0.13 | 2.21 | neg | 58 | 1.9 ± 0.3 | 2.26 | neg |
| GC13 | Her2 pos | 3.96 ± 0.6 | 3.15 | pos | 30 | 2.2 ± 0.4 | 1.94 | neg |
| GC15 | Her2 pos | 16.8 ± 4.7 | 16.3 | pos | 2 | 1.9 ± 0.4 | 1.53 | neg |
| GC2 | Her2 pos | 11.5 ± 4.1 | 11.5 | pos | 1 | 6.2 ± 1.3 | 7.4 | pos |
| GC20 | Her2 pos | 55.1 ± 12.3 | 33 | pos | 7 | 2.2 ± 0.1 | 2.38 | neg |
| GC21 | Her2 pos | 12.1 ± 1.0 | 11.26 | pos | 3 | 1.9 ± 0.3 | 1.74 | neg |
| GC22 | Her2 pos | 49 ± 5.5 | 23.4 | pos | 0 | 30.3 ± 6.1 | 17.4 | pos |
| GC5 | Her2 pos | 2.9 ± 0.5 | 2.57 | pos | 5 | 2.0 ± 0.4 | 1.9 | neg |
| GC7 | Her2 pos | 3.4 ± 0.6 | 2.35 | pos*2 | 73 | 2.2 ± 0.6 | 1.8 | neg |
| GC8 | Her2 pos | 4.7 ± 0.3 | 2.13 | pos*2 | 60 | 2.1 ± 0.2 | 1.97 | neg |
| GC9 | Her2 pos | 4.2 ± 1.4 | 5.2 | pos | 17 | 1.9 ± 0.3 | 1.74 | neg |
| GC19 | Her2 pos | na | na | No tissue | 12 | 1.9 ± 0.4 | 1.8 | neg |