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. 2023 Nov 2;78:101831. doi: 10.1016/j.molmet.2023.101831

Figure 2.

Figure 2

GIPR-Q350 mice recapitulate human GIPR-Q354 body weight increase. A-D. 8 weeks old GIPR-E350 and GIPR-Q350 female (A&B) and male (C&D) mice were monitored for their weights (A&C) and 2 h fasted blood glucose levels (B&D) over time. (n = 6 mice/genotype). E&F. 8–9 weeks old GIPR-E350 and GIPR-Q350 male mice were fed a 60 % fat diet and their weights (E) and 2 h fasted blood glucose levels (F) were monitored over time. G&H. Fat mass (G) and Lean mass (H) compared to body mass as determined by MRI after 8 weeks on the HFD. I. Total daily energy expenditure (TEE) in relation to fat mass in HFD-fed males. J&K. Indirect food intake measurements (J) and respiratory exchange ratio (RER) (K) of GIPR-E350 and GIPR-Q350 HFD-fed males over one light/dark cycle (24 h). (n = 6 mice/genotype). Data are mean ± SEM. Two tailed unpaired t-tests for A-F.