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. 2023 Nov 2;78:101831. doi: 10.1016/j.molmet.2023.101831

Figure 3.

Figure 3

GIPR-Q350 mice are more glucose tolerant than GIPR-E350 mice. A. Blood glucose excursion and area under the curve (AUC, insert) over time after an oral glucose tolerance test (OGTT, 2 g/kg) in 6 h fasted normal chow diet-fed GIPR-E350 and GIPR-Q350 females. (n = 8 mice/genotype, 13 weeks old mice). B&C. Plasma levels of Insulin (B) and GIP (C) before and at the indicated times after glucose administration (2 g/kg). (n = 8 mice/genotype, 13 weeks old mice). D. Blood glucose excursion and area under the curve (AUC, insert) over time after an oral glucose tolerance test (OGTT, 2 g/kg) in 6 h fasted normal chow diet-fed GIPR-E350 and GIPR-Q350 males. (n = 8 mice/genotype, 13 weeks old mice). E&F. Plasma levels of Insulin (E) and GIP (F) before and at the indicated times after glucose administration (2 g/kg). (n = 8 mice/genotype, 13 weeks old mice). G-I. Blood glucose excursion (G), area under the curve (AUC, H&I) over time after an intraperitoneal glucose tolerance test (2 g/kg) supplemented or not with GIP (20 μmol/kg) in 16 h fasted GIPR-E350 and GIPR-Q350 normal chow diet-fed females. (n = 8 independent experiments, 9–19 weeks old females). J-L. Blood glucose excursion (J),area under the curve (AUC, K&L) over time after an intraperitoneal glucose tolerance test (2 g/kg) supplemented or not with GIP (20 μmol/kg) in 16 h fasted GIPR-E350 and GIPR-Q350 normal chow diet-fed males. (n = 9 independent experiments, 8–26 weeks old males). Data are mean ± SEM. Two tailed unpaired t-tests for A, C,F. Two tailed paired t-tests for B, C, E, F, H,I,K,L.