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. 2023 Nov 2;78:101831. doi: 10.1016/j.molmet.2023.101831

Figure 4.

Figure 4

GIPR-Q350 mice are more sensitive to GIP than GIPR-E350 mice. A-B. Blood glucose excursion (A&B) and area under the curve (C) after an intraperitoneal glucose challenge (2 g/kg of body weight) assessed 30 min after an i.p. injection of either vehicle (PBS) or different doses of [D-Ala2]-GIP (0.1 μg, 0.5 μg, 1 μg) in 16 h fasted GIPR-E350 (A) and GIPR-Q350 (B) normal chow diet-fed female mice. D. Plasma levels of Insulin at 15 min after IP-GTT (n = 7–16 mice/genotype, 20–25 weeks old mice). E-G. Blood glucose excursion (E&F) and area under the curve (G) after an intraperitoneal glucose challenge (2 g/kg of body weight) assessed 30 min after an i.p. injection of either vehicle (PBS) or different doses of [D-Ala2]-GIP (0.1 μg, 0.5 μg, 1 μg) in 16 h fasted GIPR-E350 (E) and GIPR-Q350 (F) normal chow diet-fed male mice. H. Plasma levels of Insulin at 15 min after IP-GTT (n = 6–10 mice/genotype, 19–21 weeks old mice). Two tailed unpaired t-tests for C, D, G, H.