Table 3.
Demographics and clinical characteristics of the development and validation cohorts.
| Development cohort (N = 4600) | Validation cohort (N = 3345) | P value | |
|---|---|---|---|
| Age, years | 0.149 | ||
| 40–49 | 1271 | 910 | |
| 50–59 | 1593 | 1105 | |
| 60–69 | 1283 | 955 | |
| >69 | 453 | 375 | |
| Gender | 0.703 | ||
| Female | 2366 | 1706 | |
| Male | 2234 | 1639 | |
| Body mass index | 0.608 | ||
| ≤18.5 | 268 | 203 | |
| 18.5–23.9 | 2809 | 2006 | |
| >23.9 | 1523 | 1136 | |
| Helicobacter pylori | 0.619 | ||
| Negative | 2629 | 1893 | |
| Positive | 1971 | 1452 | |
| CEA | 0.451 | ||
| Negative | 4444 | 3221 | |
| Positive | 156 | 124 | |
| PG I, ng/mL | 0.773 | ||
| ≤42.16 | 230 | 159 | |
| 42.16–56.51 | 231 | 177 | |
| >56.51 | 4139 | 3009 | |
| PG II, ng/mL | 0.825 | ||
| ≤5.47 | 1152 | 826 | |
| 5.47–9.80 | 1383 | 994 | |
| >9.80 | 2065 | 1525 | |
| PG I/II ratio | 0.657 | ||
| ≥5.25 | 4142 | 3022 | |
| <5.25 | 458 | 323 | |
| G-17, pmol/L | 0.107 | ||
| ≤1.00 | 931 | 621 | |
| 1.00–7.98 | 2289 | 1733 | |
| >7.98 | 1380 | 991 | |
| Family history | 0.803 | ||
| No | 3993 | 2910 | |
| Yes | 607 | 435 | |
| Smoking | 0.394 | ||
| No | 3527 | 2592 | |
| Yes | 1073 | 753 | |
| Alcohol drinking | 0.624 | ||
| No | 3789 | 2741 | |
| Yes | 811 | 604 | |
| High salt diet | 0.727 | ||
| Occasional | 2657 | 1919 | |
| Regular | 1943 | 1426 | |
| Red meat | 0.130 | ||
| Occasional | 1887 | 1429 | |
| Regular | 2713 | 1916 | |
| White meat | 0.766 | ||
| Occasional | 2541 | 1859 | |
| Regular | 2059 | 1486 | |
| Green vegetables | 0.205 | ||
| Occasional | 916 | 628 | |
| Regular | 3684 | 2717 | |
| Fresh fruits | 0.376 | ||
| Occasional | 2150 | 1597 | |
| Regular | 2450 | 1748 | |
| OLGIM Stage, n (%) | 0.649 | ||
| No IM | 2944 | 2106 | |
| I | 1269 | 966 | |
| II | 263 | 187 | |
| III-IV | 124 | 86 |
CEA, carcinoembryonic antigen; PG, pepsinogen; G-17, gastrin-17; IM, intestinal metaplasia; OLGIM, Operative Link on Gastritis Intestinal Metaplasia.