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. 2023 Oct 24;26(11):108319. doi: 10.1016/j.isci.2023.108319

Figure 4.

Figure 4

RNAseq analysis of white-tailed deer (WTD) nasopharyngeal swabs comparing uninfected WTD with SARS-CoV-2 infected WTD (4055 and 4249)

(A) Relative expression levels of significant (adjusted p value <0.05) differentially expressed genes with an absolute fold change greater than 3. WTD genes with human orthologs annotated with the Gene Ontology “innate immune response” term indicated underneath.

(B) Volcano plot of the DESeq2 differential gene expression analysis results. Where possible, genes were labeled with their inferred human ortholog gene name. The upper interferon induced transmembrane protein 1 (IFITM1) is associated with LOC110149600 and the lower IFITM1 is associated with LOC110149612 in the WTD genome.

(C) Gene Ontology function enrichment of the significant up and down-differentially expressed genes against a WTD genome background with DAVID. Only terms from biological processes (black dots) and molecular functions (gray dots) are displayed. See also Figures S3 and S4 and Tables S3, S4, S5, S6, and S7.