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. 2023 Nov 9;10:1278795. doi: 10.3389/fcvm.2023.1278795

Figure 4.

Figure 4

Arterial remodeling in the vascular aging phenotypes. A diagram of the different types of arterial remodeling with normal aging. The proximal large elastic arteries, such as the thoracic aorta, carotids, and abdominal aorta, enlarge (eccentric remodeling) and become stiffer with aging, while the distal medium-sized muscular arteries do not enlarge with age and their distensibility does not change. In both places, normal aging is associated with medial hypertrophy (hypertrophic remodeling). The EVA phenomenon is accompanied by a reduction in the lumen diameter and is associated with an increased media/lumen (M/L) ratio. With supernormal vascular aging (SUPERNOVA), the vascular area increases.