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. 2023 Nov 9;14:1205834. doi: 10.3389/fimmu.2023.1205834

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Copyright © 2023 Cai, Shen, Yang, Shao, Gu, Mou and Che

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin alleviated hyperglycemia and kidney injury in type 2 diabetic mice in vivo. (A) Body weight of normal (Ctrl), diabetic (Case), and dapagliflozin-treated diabetic (Dapa) 14-week-old mice. (B) Blood glucose levels of 14-week-old mice in the Ctrl, Case, and Dapa groups. (C) Serum creatinine levels of 14-week-old mice in the Ctrl, Case, and Dapa groups. (D) Blood urea nitrogen levels of 14-week-old mice in the Ctrl, Case, and Dapa groups. (E) Urinary albumin creatinine ratio of 14-week-old mice in the Ctrl, Case, and Dapa groups. (F) Periodic acid–Schiff (PAS)–stained sections of 14-week-old mouse kidneys in the Ctrl, Case, and Dapa groups. NS, not significant. *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA test. Bar = 20 μm.