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. 2023 Nov 9;14:1205834. doi: 10.3389/fimmu.2023.1205834

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Copyright © 2023 Cai, Shen, Yang, Shao, Gu, Mou and Che

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined ATAC and RNA sequencing revealed potential candidate genes for diabetic kidney disease. (A) Violin plot of RNA sequencing indicating Isg15, Csf2rb, and Btla as potential candidate genes that were upregulated in diabetic mouse kidneys and downregulated by dapagliflozin treatment (Isg15 and Csf2rb), or downregulated in diabetic mouse kidneys and upregulated by dapagliflozin treatment (Btla). (B) ATAC analysis indicating elevated chromatin accessibility of Isg15 in diabetic mouse kidneys that was reduced by dapagliflozin treatment, with corresponding quantifications in (C). (D) ATAC analysis indicating decreased chromatin accessibility of Btla in diabetic mouse kidneys that was augmented by dapagliflozin treatment, with corresponding quantifications in (E). (F) ATAC analysis indicating elevated chromatin accessibility of Csf2rb in diabetic mouse kidneys that was reduced by dapagliflozin treatment, with corresponding quantifications in (G).