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. 2023 Nov 9;14:1205834. doi: 10.3389/fimmu.2023.1205834

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Copyright © 2023 Cai, Shen, Yang, Shao, Gu, Mou and Che

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dapagliflozin attenuated kidney injury and alleviated renal inflammation in an ischemia/reperfusion-induced mouse CKD model. (A) Serum creatinine levels of normal (Ctrl), dapagliflozin-treated normal (Ctrl+Dapa), ischemia/reperfusion-operated (I/R), and dapagliflozin-treated I/R (I/R+Dapa) 14-week-old mice. (B) Blood urea nitrogen levels of 14-week-old mice in the Ctrl, Ctrl+Dapa, I/R, and I/R+Dapa groups. (C) blood glucose levels of 14-week-old mice in the Ctrl, Ctrl+Dapa, I/R, and I/R+Dapa groups. (D) Western blot analysis showing BTLA and ISG15 protein levels in mouse kidneys in the Ctrl, Ctrl+Dapa, I/R, and I/R+Dapa groups, with corresponding quantifications in (E). NS, not significant. *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA test.