Fig. 7.
Reduced NASH phenotypes were demonstrated in the liver-specific Shp-null (LvShp−/−) mice after 6 months of WD regimen. Albumin-Cre (AlbCre) mice, Shpflox/flox (fShp) mice, and liver-specific SHP-null (LvShpKO) mice were challenged with 6 months of WD feeding. A: Liver-specific deletion of Shp gene was assessed with different tissues using qPCR analysis. ∗∗∗P < 0.005 compared with both fShp and AlbCre mice. B: Hepatic TG contents were measured with all three groups of mice. C: Expression of hepatic inflammatory and fibrogenic genes from AlbCre mice and LvShpKO mice was measured using qPCR analysis (n = 5–6). #comparison with control diet (CD), ∗comparison with AlbCre counterparts. Three symbols represent P < 0.005, two symbols P < 0.01, and one symbol P < 0.05. Int; intestine; Lv; liver; Pan, pancreas.