Table 2. 1,3-Thiazolidine-4-one Derivatives Binding Affinities (in kcal/mol) to AURKA and VEGFR-2.
| binding affinity with (kcal/mol) |
||
|---|---|---|
| compound | AURKA | VEGFR-2 |
| temozolomide | –5.7 | –5.9 |
| 1,3-Thiazolidine-4-one Derivatives | ||
| 5a | –9.8 | –8.2 |
| 5b | –9.0 | –8.7 |
| 5c | –8.9 | –9.0 |
| 5d | –9.2 | –8.1 |
| 5e | –8.7 | –7.9 |
| 5f | –8.0 | –9.4 |
| 5g | –8.5 | –9.2 |
| 5h | –8.6 | –8.7 |