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. 2023 Nov 10;8(46):43596–43609. doi: 10.1021/acsomega.3c04662

Table 2. 1,3-Thiazolidine-4-one Derivatives Binding Affinities (in kcal/mol) to AURKA and VEGFR-2.

  binding affinity with (kcal/mol)
compound AURKA VEGFR-2
temozolomide –5.7 –5.9
1,3-Thiazolidine-4-one Derivatives
5a –9.8 –8.2
5b –9.0 –8.7
5c –8.9 –9.0
5d –9.2 –8.1
5e –8.7 –7.9
5f –8.0 –9.4
5g –8.5 –9.2
5h –8.6 –8.7