Table 3.

Diagnostic criteria for IgG4-related hypophysitis.

Diagnostic criteria for IgG4-related hypophysitis
Criterion 1: Pituitary histopathology
Mononuclear infiltration of the pituitary gland, rich in lymphocytes and plasma cells, with more than 10 IgG4- positive cells per high-power field
Criterion 2: Pituitary MRI
Sellar mass and/or thickened pituitary stalk
Criterion 3: Biopsy-proven involvement in other organs
Association with IgG4-positive lesions in other organs
Criterion 4: Serology
Increased serum IgG4 (140 mg/dL)
Criterion 5: Response to glucocorticoids
Shrinkage of the pituitary mass and symptom improvement with steroids.
Diagnosis of IgG4-related hypophysitis is established when any of the following is fulfilled:
Criterion 1
Criteria 2 and 3
Criteria 2, 4, and 5