Table 1.
Basic characteristics of genotyped participants of European ancestry in the selected studies.
| Sample | All | AD cases | DM cases | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Men (%) | Age, mean (SD), years | N | Men (%) | Age, mean (SD), years | N | Men (%) | Age, mean (SD), years | |
| ADGC | 5349 | 44.59 | 78.53 (8.5) | 3585 | 46.97 | 79.72 (7.71) | |||
| ADSP | 1568 | 60.52 | 76.86 (10.92) | 998 | 61.72 | 74.20 (12.02) | |||
| ARIC | 9631 | 47.00 | 75.34 (6.85) | 2044 | 53.91 | 75.23 (7.03) | |||
| CHS | 3262 | 39.79 | 83.63 (5.16) | 201 | 34.83 | 85.35 (4.86) | 440 | 50.68 | 83.08 (5.11) |
| FHS | 3761 | 43.84 | 79.23 (10.13) | 361 | 31.02 | 89.41 (6.94) | 660 | 56.52 | 79.48 (9.06) |
| GenADA | 1588 | 38.98 | 75.76 (8.59) | 806 | 42.18 | 78.05 (8.60) | 143 | 44.76 | 77.23 (7.37) |
| LOADFBS | 3299 | 38.83 | 75.62 (11.61) | 1507 | 35.70 | 85.50 (8.45) | 309 | 52.10 | 77.99 (10.01) |
| MESA | 2526 | 47.74 | 72.69 (9.92) | 382 | 53.14 | 73.10 (9.77) | |||
| ROSMAP | 871 | 32.95 | 86.28 (4.65) | 486 | 30.25 | 87.31 (3.91) | |||
| UKB, 60+ | 333208 | 45.99 | 69.32 (5.10) | 913 | 51.04 | 72.67 (4.63) | 24723 | 61.22 | 68.78 (6.85) |
AD denotes Alzheimer’s disease; DM denotes diabetes mellitus; SD denotes standard deviation.
ADGC is the National Institute on Aging (NIA) AD Genetics Consortium (ADGC) dataset, which includes data from three AD Centers (ADC1, ADC2, and ADC3); ADSP is the NIA AD Sequencing Project; ARIC is the Atherosclerosis Risk in Communities study; CHS is the Cardiovascular Health Study; FHS is the Framingham Heart Study parental and offspring cohorts; GenADA is the Multi-Site Collaborative Study for Genotype-Phenotype Associations in AD; LOADFBS is the NIA Late-Onset Alzheimer Disease Family-Based Study; MESA is the Multi-Ethnic Study of Atherosclerosis; ROSMAP is the Religious Orders Study and Memory and Aging Project; and UKB is the UK Biobank dataset.
Age was defined as the age of death or censoring for ADGC, ARIC, CHS, FHS, MESA, ROSMAP, and UKB. For LOADFBS and GenADA, age was provided at the launch of the study. ADSP defined age as the age at the onset of AD or the age at the last follow-up.
The UKB sample was limited to subjects who were 60 years and older.
Blank cells indicate not available information.