Table 2.
The results of the univariate and pleiotropic meta-analyses of the associations of the lead SNPs in three clusters with Alzheimer’s disease (AD) and diabetes mellitus (DM) from the discovery and replication samples.
| SNP ID | Position | Cytoband | Cluster | Alleles | Sex | Pleiotropy | Univariate AD | Univariate DM | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P Fisher | P omnibus | β AD | SEAD | P AD | β DM | SEDM | P DM | ||||||
| rs5025718 | 119935662 | 1p12 | NOTCH2 | C/T | M&W | 3.88E-10 | 6.37E-10 | 0.111 | 0.038 | 3.48E-03 | 0.076 | 0.013 | 4.30E-09 |
| W | 1.21E-04 | 1.02E-04 | 0.058 | 0.060 | 3.36E-01 | 0.071 | 0.017 | 2.88E-05 | |||||
| M | 1.93E-06 | 3.10E-06 | 0.150 | 0.052 | 4.06E-03 | 0.084 | 0.020 | 2.80E-05 | |||||
| rs9275476 | 32704847 | 6p21.32 | HLA | T/C | M&W | 3.38E-25 | 1.62E-25 | −0.241 | 0.042 | 1.16E-08 | 0.125 | 0.014 | 4.75E-19 |
| W | 4.43E-13 | 3.22E-13 | −0.216 | 0.064 | 7.42E-04 | 0.122 | 0.018 | 1.81E-11 | |||||
| M | 1.13E-12 | 9.82E-13 | −0.261 | 0.059 | 1.03E-05 | 0.129 | 0.022 | 3.44E-09 | |||||
| rs9275599 | 32714652 | 6p21.32 | HLA | C/T | M&W | 6.73E-24 | 3.40E-24 | −0.205 | 0.042 | 1.20E-06 | 0.130 | 0.014 | 9.63E-20 |
| W | 4.28E-14 | 2.66E-14 | −0.205 | 0.065 | 1.46E-03 | 0.133 | 0.019 | 8.31E-13 | |||||
| M | 4.13E-10 | 3.31E-10 | −0.192 | 0.059 | 1.08E-03 | 0.126 | 0.022 | 1.48E-08 | |||||
| rs429358 | 44908684 | 19q13.32 | APOE | T/C | M&W | <1E-302 | <1E-302 | 1.305 | 0.031 | <1E-302 | −0.080 | 0.013 | 1.91E-10 |
| W | 1.42E-136 | 4.84E-138 | 1.179 | 0.048 | 5.57E-133 | −0.080 | 0.016 | 7.98E-07 | |||||
| M | 1.89E-210 | 2.58E-212 | 1.371 | 0.044 | 6.58E-209 | −0.079 | 0.020 | 5.86E-05 | |||||
Column Position is a chromosome position in base pairs given in Genome Reference Consortium Human Build 38 (GRCh38).
Column Alleles shows major/minor alleles. A minor allele was used as an effect allele.
Column Sex indicates samples of men (M) and women (W) combined (M&W) and separately.
Column Pleiotropy shows p-values from the pleiotropic meta-analysis using Fisher’s method (PFisher) and the omnibus test (Pomnibus).
Columns Univariate AD and Univariate DM show effect sizes (β), standard errors (SE), and p-values (P) from the univariate meta-analysis of AD and DM, respectively.