Table 3.
Disease | Chr | Cluster | Lead-SNP-unadjusted models | Lead-SNP-adjusted models | ||
---|---|---|---|---|---|---|
NSNPs | Significance | NSNPs | Significance | |||
AD | 6 | HLA | 174 | 1.16E-8≤p≤3.29E-2 | 91 | 3.68E-3≤p≤4.69E-2 |
DM | 6 | HLA | 174 | 9.63E-20≤p≤3.79E-7 | 105 | 7.47E-12≤p≤3.90E-2 |
AD | 19 | APOE | 75 | p≤1.70E-14 | 36 | 1.81E-11≤p≤4.74E-2 |
DM | 19 | APOE | 75 | 1.91E-10≤p≤4.66E-2 | 4 | 1.76E-2≤p≤4.27E-2 |
Chr denotes chromosome
Columns Lead-SNP-unadjusted models and Lead-SNP-adjusted models show the number of AD- or DM-associated SNPs (NSNPs) and the range of p-values in the univariate meta-analyses of the discovery and replication samples in HLA and APOE gene clusters. Detailed information on the univariate and pleiotropic associations is given in Supplementary Table 1 for the lead-SNP-unadjusted models and Supplementary Tables 2 and 3 for the lead-SNP-adjusted models in the APOE and HLA gene clusters, respectively.