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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: J Alzheimers Dis. 2023;94(3):1121–1132. doi: 10.3233/JAD-230397

Table 3.

Summary information on 249 SNPs showing pleiotropic associations with Alzheimer’s disease (AD) and diabetes mellitus (DM) in the APOE and HLA gene clusters.

Disease Chr Cluster Lead-SNP-unadjusted models Lead-SNP-adjusted models
NSNPs Significance NSNPs Significance
AD 6 HLA 174 1.16E-8≤p≤3.29E-2 91 3.68E-3≤p≤4.69E-2
DM 6 HLA 174 9.63E-20≤p≤3.79E-7 105 7.47E-12≤p≤3.90E-2
AD 19 APOE 75 p≤1.70E-14 36 1.81E-11≤p≤4.74E-2
DM 19 APOE 75 1.91E-10≤p≤4.66E-2 4 1.76E-2≤p≤4.27E-2

Chr denotes chromosome

Columns Lead-SNP-unadjusted models and Lead-SNP-adjusted models show the number of AD- or DM-associated SNPs (NSNPs) and the range of p-values in the univariate meta-analyses of the discovery and replication samples in HLA and APOE gene clusters. Detailed information on the univariate and pleiotropic associations is given in Supplementary Table 1 for the lead-SNP-unadjusted models and Supplementary Tables 2 and 3 for the lead-SNP-adjusted models in the APOE and HLA gene clusters, respectively.

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