Table 2. Average Number of H-Bonds between the Y1278–C1097 and E1167–K1150 Interactions over the MDSs of ALK WT and I1171N/S/T Mutations in Apo and ATP-Bound States.

	average H-bonds between interaction
MD-trajectories	Y1278–C1097	E1167–K1150
WT-Apo	0.088346	0.239138
I1171N-Apo	0.017149	0.502625
I1171S-Apo	0.100095	0.39898
I1171T-Apo	0.033648	0.438528
WT-ATP	0.0013	0.318734
I1171N-ATP	0.010049	0.532423
I1171S-ATP	0.095545	0.40978
I1171T-ATP	0.034898	0.109695