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. 2023 Nov 8;8(46):43586–43595. doi: 10.1021/acsomega.3c04492

Table 2. SUVmean Values for Anti-MSLN PET Tracers.

[89Zr]Zr-DFO-5–2A10-VH-Fc (n = 3)   tumor heart blood muscle tumor: muscle tumor: heart tumor:blood
  90 m 0.46 ± 0.23 4.53 ± 2.01 4.33 ± 1.50 0.18 ± 0.09 2.48 ± 0.89 0.10 ± 0.01 0.10 ± 0.03
18 h 1.91 ± 0.38 1.38 ± 0.27 1.38 ± 0.34 0.24 ± 0.12 9.34 ± 3.71 1.39 ± 0.19 1.40 ± 0.20
48 h 2.08 ± 0.60 0.91 ± 0.29 0.90 ± 0.36 0.21 ± 0.11 10.88 ± 2.95 2.31 ± 0.26 2.60 ± 1.40
96 h 1.38 ± 0.31 0.74 ± 0.16 0.69 ± 0.58 0.13 ± 0.05 12.25 ± 5.76 1.87 ± 0.02 2.51 ± 1.88
144 h 1.18 ± 0.21 0.75 ± 0.17 1.17 ± 0.28 0.14 ± 0.05 8.71 ± 1.53 1.59 ± 0.13 1.08 ± 0.39
[89Zr]Zr-DFO-5–3C9- VH-Fc (n = 4)   tumor heart blood muscle tumor: muscle tumor: heart tumor: blood
  90 m 0.26 ± 0.25 3.08 ± 2.65 2.82 ± 2.45 0.12 ± 0.03 2.41 ± 2.54 0.11 ± 0.06 0.06 ± 0.07
18 h 1.07 ± 0.48 1.26 ± 0.43 1.44 ± 0.28 0.20 ± 0.08 6.72 ± 4.49 0.98 ± 0.58 0.77 ± 0.37
48 h 1.00 ± 0.39 0.80 ± 0.20 1.00 ± 0.40 0.16 ± 0.07 8.08 ± 5.78 1.33 ± 0.60 1.01 ± 0.07
96 h 0.82 ± 0.33 0.65 ± 0.14 0.67 ± 0.22 0.15 ± 0.05 6.71 ± 4.52 1.31 ± 0.57 1.47 ± 1.34
144 h 0.84 ± 0.15 0.66 ± 0.18 0.72 ± 0.37 0.18 ± 0.06 5.29 ± 2.36 1.29 ± 0.14 1.35 ± 0.42
[89Zr]Zr-DFO-5-m912 IgG1(n = 4)   tumor heart blood muscle tumor: muscle tumor: heart tumor: blood
  90 m              
18 h 0.86 ± 0.12 1.50 ± 0.31 1.44 ± 0.11 0.22 ± 0.17 5.85 ± 3.51 0.61 ± 0.23 0.60 ± 0.12
48 h 0.54 ± 0.21 0.62 ± 0.09 1.07 ± 0.56 0.12 ± 0.05 5.56 ± 3.03 0.87 ± 0.26 0.82 ± 0.51
96 h 0.62 ± 0.29 0.73 ± 0.07 0.92 ± 0.26 0.11 ± 0.02 5.70 ± 2.73 0.84 ± 0.34 0.65 ± 0.17
144 h 0.73 ± 0.37 0.76 ± 0.08 1.35 ± 0.43 0.18 ± 0.11 5.78 ± 4.96 0.96 ± 0.45 0.45 ± 0.27
[89Zr]Zr-DFO-5–3C9- VH-Fc (n = 4)   tumor heart blood muscle tumor: muscle tumor: heart tumor: blood
  90 m 0.26 ± 0.25 3.08 ± 2.65 2.82 ± 2.45 0.12 ± 0.03 2.41 ± 2.54 0.11 ± 0.06 0.06 ± 0.07
18h 1.07 ± 0.48 1.26 ± 0.43 1.44 ± 0.28 0.20 ± 0.08 6.72 ± 4.49 0.98 ± 0.58 0.77 ± 0.37
48 h 1.00 ± 0.39 0.80 ± 0.20 1.00 ± 0.40 0.16 ± 0.07 8.08 ± 5.78 1.33 ± 0.60 1.01 ± 0.07
96 h 0.82 ± 0.33 0.65 ± 0.14 0.67 ± 0.22 0.15 ± 0.05 6.71 ± 4.52 1.31 ± 0.57 1.47 ± 1.34
144 h 0.84 ± 0.15 0.66 ± 0.18 0.72 ± 0.37 0.18 ± 0.06 5.29 ± 2.36 1.29 ± 0.14 1.35 ± 0.42
[89Zr]Zr-DFO-5-m912 IgG1(n = 4)   tumor heart blood muscle tumor: muscle tumor: heart tumor: blood
  90 m              
18h 0.86 ± 0.12 1.50 ± 0.31 1.44 ± 0.11 0.22 ± 0.17 5.85 ± 3.51 0.61 ± 0.23 0.60 ± 0.12
48 h 0.54 ± 0.21 0.62 ± 0.09 1.07 ± 0.56 0.12 ± 0.05 5.56 ± 3.03 0.87 ± 0.26 0.82 ± 0.51
96 h 0.62 ± 0.29 0.73 ± 0.07 0.92 ± 0.26 0.11 ± 0.02 5.70 ± 2.73 0.84 ± 0.34 0.65 ± 0.17
144 h 0.73 ± 0.37 0.76 ± 0.08 1.35 ± 0.43 0.18 ± 0.11 5.78 ± 4.96 0.96 ± 0.45 0.45 ± 0.27