Table 2. Mediation analysis for the relationship between a fish-based diet, obesity, and the incidence of diabetes (12).

	Hazard ratio [95% CI]*
Total effect	0.56 [0.43; 0.67]
Direct effect	0.70 [0.53; 0.87]
Indirect effect (via obesity)	0.81 [0.79; 0.83]
“proportion mediated” (%)	30.6 [16.9; 56.0]

* Effects are specified for a fish-based diet compared with a meat-based diet. Adjusted for age, sex, deprivation, alcohol consumption, smoking, physical inactivity, sleep duration, and type of physical activity.

95% CI, 95% confidence interval