Table 1.

Classification of MISC and Methylprednisolone Dosing Based on Severity

	Mild	Moderate	Severe (ICU care)
Respiratory support	None	None or minimal or significant	None or minimal or significant
Cardiovascular support	None	None or minimal	Vaso actives or inotropes
End organ injury	Minimal	Mild or isolated	Severe or multi-organ
Initial dose (mg/kg/day) Maintenance daily dose	None or minimal	10 mg/kg (max 1 g) x 1–3 days 2 mg/kg (max 60 mg) x 5 days	20-30 mg/kg (max 1 g) x 1–3 days 2 mg/kg (max 60 mg) x 5 days