Table 2.
Prospective quantitative analysis of white blood cell subpopulations and C-reactive protein in stroke patients and controls
| Stroke D1 N = 52 |
Stroke D3 N = 52 |
Stroke D10 N = 51 |
Stroke D90 N = 33 |
Disease control group N = 34 |
p D1 vs. DC | p D3 vs. DC | p D10 vs. DC | p D90 vs. DC | |
|---|---|---|---|---|---|---|---|---|---|
| WBC × 103/µl |
7.4 (5.8–10.6) |
7.6 (5.7–10.2) |
7.2 (5.9–8.1) |
6.8 (5.6–7.7) |
6.8 (5.7–8.4) |
0.12 | 0.28 | 0.82 | 0.45 |
| Lymphocytes × 103/µl | 1.7 ± 0.9 | 2.0 ± 0.9 | 1.8 ± 0.7 | 1.9 ± 0.7 | 2.3 ± 1.2 | 0.008 | 0.01 | 0.02 | 0.07 |
| Lymphocytes % | 21.5 ± 11.6* | 25.3 ± 10.9 | 25.8 ± 10.2 | 28 ± 7.5 | 31.3 ± 10 | < 0.0001 | 0.02 | 0.03 | 0.16 |
|
Treg (cells/μl) |
13.2 (8.6–19.8) |
15.4 (9.2–27.4) |
12.9 (8.7–18.2) |
14.5 (10.2–20.7) |
16.4 (9.07–21.1) |
0.61 | 0.62 | 0.42 | 0.91 |
|
Treg H+ (cells/μl) |
8.0 (4.9–15.8) |
9.1 (4.0–21.2) |
6.1 (4.6–12.9) |
9.4 (7.5–15.9) |
13.8 (7.1–18.6) |
0.03 | 0.04 | 0.03 | 0.27 |
|
Treg H− (cells/μl) |
4.6 (2.6–6.81) |
4.7 (3.5–9.8) |
5.3 (3.9–7.3) |
4.3 (1.0–8.5) |
1.0 (0.5–3.1) |
< 0.0001 | < 0.0001 | < 0.0001 | 0.006 |
| H−/H+ Treg ratio |
0.5 (0.3–0.9) |
0.6 (0.4–1.0) |
0.6 (0.5–0.8) |
0.2 (0.1–1.0) |
0.05 (0.02–0.15) |
< 0.0001 | < 0.0001 | < 0.0001 | 0.001 |
| CRP, mg/L | 4.2 (1.8–9.9)* | 6.1 (2.1–22.1)* | 3.8 (1.2–19.2)* | 1.9 (0.4–5) | 1.2 (0.6–2.2) | 0.001 | < 0.0001 | 0.03 | 0.23 |
p-values in bold are statistically significant
*Difference significant in relation to the value observed on D90 (p < 0.001). No other significant differences between D1-D3-D10-D90 were observed