Table 1.
Demographics and baseline characteristics (FAS)
| SAD group | MAD group | FE group | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo (n = 14) | 5 mg (n = 8) | 10 mg (n = 8) | 20 mg (n = 8) | 30 mg (n = 8) | 40 mg (n = 8) | 60 mg (n = 4) | 80 mg (n = 4) | Placebo (n = 4) |
30 mg (n = 8) | 40 mg (n = 8) | A (n = 8) |
B (n = 8) |
|
| Age | |||||||||||||
| Mean (SD) | 22.7 (3.0) | 23.8 (5.3) | 23.4 (4.2) | 22.0 (4.0) | 21.4 (3.5) | 22.9 (3.0) | 26.5 (5.7) | 22.3 (5.2) | 21.3 (3.0) | 23.5 (2.1) | 24.5 (6.2) | 23.9 (3.2) | 23.9 (4.0) |
| Median (range) | 22.5 (19–28) | 22.0 (19–34) | 22.0 (19–32) | 21.5 (18–31) | 20.0 (19–29) | 23.5 (18–26) | 26.5 (20–33) | 20.0 (19–30) | 21.0 (18–25) | 23.5 (21–26) | 21.5 (18–35) | 23.0 (19–28) | 24.5 (19–29) |
| Sex (%) | |||||||||||||
| Male | 8 (57.1) | 5 (62.5) | 5 (62.5) | 4 (50.0) | 5 (62.5) | 5 (62.5) | 2 (50.0) | 3 (75.0) | 2 (50.0) | 5 (62.5) | 4 (50.0) | 4 (50.0) | 4 (50.0) |
| Female | 6 (42.9) | 3 (37.5) | 3 (37.5) | 4 (50.0) | 3 (37.5) | 3 (37.5) | 2 (50.0) | 1 (25.0) | 2 (50.0) | 3 (37.5) | 4 (50.0) | 4 (50.0) | 4 (50.0) |
| Height | |||||||||||||
| Mean (SD) | 163.5 (7.6) | 162.1 (4.4) | 167.7 (9.8) | 161.7 (9.4) | 162.0 (8.6) | 166.0 (6.6) | 164.4 (9.1) | 169.9 (7.8) | 164.8 (5.8) | 167.6 (9.9) | 163.7 (13.7) | 162.8 (8.8) | 165.0 (7.1) |
| Median (range) | 163.3 (148.0–175.5) | 161.8 (153.5–168.0) | 167.5 (151.0–183.0) | 158.8 (150.0–176.0) | 162.0 (151.5–178.0) | 165.3 (157.0–176.0) | 161.8 (156.5–177.5) | 169.3 (163.0–178.0) | 165.3 (157.5–171.0) | 169.5 (150.5–180.0) | 168.3 (146.0–185.5) | 164.0 (151.0–174.5) | 165.8 (151.5–175.5) |
| Weight | |||||||||||||
| Mean (SD) | 57.5 (7.5) | 57.0 (3.6) | 59.6 (4.1) | 53.9 (7.2) | 55.9 (5.7) | 59.3 (7.5) | 56.8 (5.7) | 57.9 (4.0) | 59.7 (3.9) | 58.9 (7.1) | 56.6 (9.4) | 56.3 (7.0) | 57.4 (8.3) |
| Median (range) | 55.9 (46.4–71.9) | 56.9 (52.3–63.8) | 59.7 (51.1–64.5) | 52.0 (45.4–66.0) | 56.0 (46.0–65.0) | 58.7 (49.2–69.4) | 54.7 (52.6–65.3) | 58.9 (52.4–61.3) | 58.8 (55.9–65.1) | 58.6 (49.2–67.4) | 55.4 (47.6–76.7) | 54.8 (49.0–69.2) | 55.9 (48.0–71.2) |
| BMI | |||||||||||||
| Mean (SD) | 21.4 (1.4) | 21.7 (1.2) | 21.2 (1.4) | 20.5 (0.6) | 21.3 (1.3) | 21.5 (1.5) | 21.0 (1.0) | 20.1 (0.9) | 22.0 (1.7) | 20.9 (1.5) | 21.0 (1.2) | 21.2 (1.2) | 21.0 (1.7) |
| Median (range) | 21.40 (19.2–23.7) | 21.80 (19.5–23.4) | 21.35 (19.3–23.3) | 20.30 (19.8–21.3) | 21.25 (19.3–23.7) | 21.10 (19.3–23.7) | 20.85 (20.0–22.3) | 19.75 (19.3–21.4) | 22.10 (20.2–23.6) | 20.60 (19.3–23.2) | 21.30 (19.4–22.3) | 21.05 (19.8–23.8) | 20.85 (19.0–23.7) |
The units of height, weight and BMI are cm, kg, kg/m2