Figure 1.

Conceptual illustration of multiplicative and toxicologically mimicked interactions. Figure 1A shows a usual multiplicative interaction between two chemicals and mapping to plausible threshold-based interactions. Figure 1B shows that a higher value of a multiplicative interaction does not imply a higher value for each of its constituents. On the other hand, Figure 1C denotes a higher value of a toxicologically mimicking interaction, implying a higher value for each of its constituents.