Extended Data Figure 3. nmrHAS2 mice showed a distinct transcriptomic signature.

a. nmrHAS2 mice display an expression signature distinct form mice subjected to other pro-longevity interventions. A heatmap of correlation analysis performed on liver whole transcriptomes.

b. Association between nmrHAS2 effect and signatures of lifespan-extending interventions and mammalian aging based on functional enrichment (GSEA) scores. Only functions enriched by at least one signature (adjusted p-value < 0.1) were used for the calculation. Exact adjusted p-values are shown in Extended Data table 2.

c. Functional enrichment (GSEA) of gene expression signatures associated with nmrHAS2, mammalian aging and established lifespan-extending interventions. Only functions significantly enriched by at least one signature (adjusted p-value < 0.1) are presented. Exact adjusted p-values are shown in Supplementary Table 4.

d. Functional enrichment (Fisher exact test) of genes significantly associated with the effect of nmrHAS2, mammalian aging and established lifespan-extending interventions. Only functions enriched by at least one aggregated signature (adjusted p-value < 0.1) are shown. Proportion of pathway-associated genes is reflected by bubble size. Exact adjusted p-values are shown in Supplementary Table 5.

b-d. ^ p.adjusted < 0.1; * p.adjusted < 0.05; ** p.adjusted < 0.01; *** p.adjusted < 0.001.