Table 3.

Therapeutic adverse events during first-line treatment, using CTCAE criteria v5.0

Adverse events	N	Grade 1–2	Grade 3–4	%
Vertebral collapse	4	4		3.9
Fractured rib	1	1		1
Intracranial bleeding	6	5	1	5.8
Other location bleeding	5	5		4.9
Wound dehiscence	1	1		1
Venous thromboembolic events	8	6	2	7.8
Thrombocytopenia ≥ grade 3	24	0	24	23.2
Neutropenia ≥ grade 3	7	0	7	6.8
Lymphopenia ≥ grade 3	15	0	15	14.6
Anemia	3	2	1	2.9
Infection without agranulocytosis	17	15	2	16.5
Arterial hypertension	2	1	1	1.9
Fatigue grade ≥ 3	9		9	8.7
Cognitive impairment	1	1		1

Values in italic are for percentages of patients for each adverse event.