Table 2.
Cox Uni- and Multi-variable Regression Analysis
| Characteristic | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age | ||||||
| 18–45 | — | — | — | — | ||
| 46–69 | 1.70 | 1.38, 2.10 | <.001 | 1.83 | 1.46, 2.29 | <.001 |
| 70+ | 3.26 | 2.61, 4.06 | <.001 | 3.86 | 3.04, 4.92 | <.001 |
| Period | ||||||
| 2003–2005 | — | — | — | — | ||
| 2006–2012 | 0.85 | 0.73, 0.98 | .030 | 0.82 | 0.70, 0.97 | 0.024 |
| 2013–2019 | 0.71 | 0.61, 0.83 | <.001 | 0.70 | 0.59, 0.82 | <.001 |
| Gender | ||||||
| Female | — | — | — | — | ||
| Male | 1.09 | 0.99, 1.21 | .087 | 1.09 | 0.98, 1.22 | .12 |
| Lobe | ||||||
| Frontal | — | — | — | — | ||
| Parietal | 1.00 | 0.86, 1.16 | >.9 | 0.99 | 0.84, 1.16 | .9 |
| Temporal | 1.02 | 0.89, 1.15 | .8 | 1.01 | 0.88, 1.15 | >.9 |
| Occipital | 1.32 | 1.09, 1.59 | .004 | 1.15 | 0.94, 1.41 | .2 |
| Insula | 1.31 | 0.87, 1.95 | .2 | 1.35 | 0.89, 2.05 | .2 |
| Corpus Callosum | 1.60 | 1.18, 2.17 | .003 | 1.41 | 0.95, 2.10 | .090 |
| Two or more regions | 1.85 | 1.56, 2.19 | <.001 | 1.65 | 1.36, 1.99 | <.001 |
| Side | ||||||
| Right | — | — | — | — | ||
| Left | 1.00 | 0.91, 1.11 | >.9 | 1.08 | 0.97, 1.20 | .2 |
| Midline | 1.46 | 0.98, 2.18 | .060 | 1.06 | 0.64, 1.75 | .8 |
| Bilateral | 2.13 | 1.61, 2.82 | <.001 | 1.35 | 1.00, 1.82 | .053 |
| EOR | ||||||
| CRCET | — | — | — | — | ||
| Subtotal | 1.74 | 1.54, 1.97 | <.001 | 1.68 | 1.47, 1.92 | <.001 |
| Biopsy | 3.30 | 2.77, 3.93 | <.001 | 2.90 | 2.38, 3.53 | <.001 |