Table 2.

Summary of rituximab reactions

Cohort	CTCAE grade	Symptoms	Infusion duration (min)	Infusion stopped	Interventions	Received 2nd dose	Tolerated 2nd dose
Cohort 1	2	Chills, vomiting	1093	N	Hydrocortisone, ranitidine	NA	NA
	2	Urticaria, cough	475	N	Hydrocortisone	NA	NA
	2	Rash, itching, vomiting	215	N		NA	NA
	2	Chills, tachycardia	83	Y	Hydrocortisone	NA	NA
	2	Tachycardia, tachypnea, hypotension, vomiting	13	Y	Lorazepam, normal saline bolus	NA	NA
	3	Wheezing, tachypnea, hypoxia, tachycardia, hypotension, vomiting	102	Y	Albuterol, epinephrine, hydrocortisone, ranitidine	NA	NA
	4	Urticaria, wheezing, hypoxia, chills, vomiting	150	Y	Diphenhydramine, epinephrine, hydrocortisone, ranitidine	NA	NA
Cohort 2	2	Urticaria	419	N	Diphenhydramine, ranitidine, hydrocortisone	N	NA
	2	Urticaria	483	N	Diphenhydramine, hydrocortisone	Y	Y
	2	Urticaria	455	N	Diphenhydramine, ranitidine, hydrocortisone	Y	Y
	2	Urticaria	463	Y	Diphenhydramine, methylprednisolone, ranitidine, hydrocortisone	N	NA
	2	Urticaria	334	Y	Acetaminophen, diphenhydramine, hydrocortisone, ranitidine	Y	Y
	2	Chills, abdominal pain	80	Y	Hydrocortisone, ranitidine	N	NA
	3	Urticaria	2179	N	Hydrocortisone, hydroxyzine, ranitidine, acetaminophen, diphenhydramine	Y	Y
	3	Cough, dyspnea, vomiting	141	Y	Albuterol, diphenhydramine, methylprednisolone, hydrocortisone, ranitidine	N	NA
	3	Urticaria, facial swelling, wheezing, dyspnea	103	Y	Albuterol, methylprednisolone, ranitidine, hydrocortisone	N	NA

Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events; min, minutes; N, no; Y, yes; NA, not applicable