Table 3.
Weighted multivariate linear regression analysis between lnSII and thyroid function.
| Model 1aβ (95% CI), p-value | Model 2bβ (95% CI), p-value | Model 3cβ (95% CI), p-value | |
|---|---|---|---|
| FT3 | |||
| lnSII | −0.0603 (−0.1078, −0.0128) ∗ | −0.0496 (−0.0991, −0.0002) | −0.0559 (−0.1060, −0.0059) ∗ |
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | −0.0242 (−0.0588, 0.0104) | −0.0131 (−0.0467, 0.0205) | −0.0180 (−0.0532, 0.0172) |
| Tertile 3 | −0.0535 (−0.0851, −0.0218) ∗ ∗ | −0.0321 (−0.0626, −0.0015) ∗ | −0.0385 (−0.0689, −0.0082) ∗ |
| p for trend | 0.002 | 0.044 | 0.019 |
| TT4 | |||
| lnSII | 0.1837 (0.0974, 0.2700) ∗ ∗ ∗ | 0.1692 (0.0873, 0.2510) ∗ ∗ ∗ | 0.1499 (0.0722, 0.2276) ∗ ∗ |
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | 0.0526 (−0.0504, 0.1555) | 0.0395 (−0.0650, 0.1439) | 0.0404 (−0.0656, 0.1464) |
| Tertile 3 | 0.2267 (0.1199, 0.3334) ∗ ∗ ∗ | 0.1885 (0.0850, 0.2921) ∗ ∗ | 0.1637 (0.0638, 0.2636) ∗ ∗ |
| p for trend | <0.001 | <0.001 | 0.004 |
| FT3/FT4 | |||
| lnSII | −0.0918 (−0.1658, −0.0178) ∗ | −0.0724 (−0.1477, 0.0029) | −0.0920 (−0.1667, −0.0173) ∗ |
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | −0.0078 (−0.0583, 0.0427) | 0.0130 (−0.0376, 0.0635) | −0.0119 (−0.0635, 0.0396) |
| Tertile 3 | −0.0761 (−0.1349, −0.0172) ∗ | −0.0403 (−0.0980, 0.0175) | −0.0635 (−0.1191, −0.0078) ∗ |
| p for trend | 0.014 | 0.174 | 0.034 |
| TG | |||
| lnSII | 1.8916 (−0.0697, 3.8529) | 2.1148 (0.1579, 4.0716) | 1.6395 (−0.1964, 3.4754) |
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | 0.1784 (−1.6907, 2.0476) | 0.5005 (−1.3938, 2.3949) | 0.1917 (−1.7884, 2.1718) |
| Tertile 3 | 3.6951 (0.6535, 6.7366) ∗ | 3.7026 (0.6588, 6.7463) ∗ | 3.1108 (0.2400, 5.9817) ∗ |
| p for trend | 0.021 | 0.022 | 0.045 |
| TPOAb | |||
| lnSII | 5.1330 (0.4263, 9.8398) ∗ | 3.7777 (−1.0059, 8.5613) | 4.0172 (−0.5236, 8.5581) |
| Tertile 1 | Reference | Reference | Reference |
| Tertile 2 | 0.8370 (−6.0170, 7.6911) | −0.3275 (−7.6876, 7.0326) | −0.7054 (−8.0546, 6.6439) |
| Tertile 3 | 5.5685 (−1.4221, 12.5590) | 3.7000 (−3.4980, 10.8980) | 3.6992 (−3.0884, 10.4868) |
| p for trend | 0.123 | 0.313 | 0.288 |
Note: FT3, free triiodothyronine; FT4, free thyroxine; TT3, total triiodothyronine; TT4, total thyroxine; TG, thyroglobulin; TGAb, thyroglobulin antibodies; and TPOAb, thyroid peroxidase antibodies. aModel 1: no covariates were adjusted. bModel 2: adjusted for age, sex, race, marital status, family poverty income ratio, and education level. cModel 3: adjusted for age, sex, race, marital status, family poverty income ratio, education level, body mass index, smoking status, alcohol use, diabetes, glycated hemoglobin, alanine aminotransferase, aspartate aminotransferase, creatinine, urine iodine concentration, and total cholesterol. ∗p < 0.05, ∗ ∗p < 0.01, ∗ ∗ ∗p < 0.001. Bold values signify the statistically significant variables clearly distinguishable from those that are not.