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. 2023 Oct 16;29(11):2919–2928. doi: 10.1038/s41591-023-02603-1

Extended Data Table 4.

ELF test and ELF components change from baseline

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This trial was designed to maintain an overall study-wise type I error rate of α = 0.05 for the key secondary end points only. The error rate was controlled by first splitting the overall two-sided α = 0.05 into 2 partitions via the Bonferroni method, and then the key secondary end points tested in a prespecified hierarchical order. For the primary analysis of key secondary lipid end points, an analysis of covariance (ANCOVA) model was used to analyze each set of 10 imputed datasets. A similar ANCOVA model was used whereby the baseline value of the dependent variable was included as covariate instead of LDL-C.CFB, change from baseline; CI, confidence interval; DB, double-blind; ELF, enhanced liver function; PIIINP, amino-terminal propeptide of type III collagen; TIMP, tissue mettaloproteinase-1; HA, hyaluronic acid