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. 2023 Oct 19;29(11):2805–2813. doi: 10.1038/s41591-023-02587-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, UMAP ordination of median-centered plasma metabolite levels revealed four distinct clusters of metabolites. b, UMAP ordination stratified according to clinical group (historic controls in blue or recipients of RPS in orange), with the largest divergence in overlap at engraftment. c, Contingency tables of plasma metabolite groups stratified according to clinical group (historical controls or recipients of RPS) at four time points with baseline to the far left, followed by nadir, then by engraftment and then by day 100 to the far right. Chi-squared contingency testing P values are reported, with only significant differences between the RPS and historical control cohorts at engraftment. d, Regression revealed a subset of metabolites driving each cluster, with cluster 3 (dominant at baseline) notable for metabolite levels close to the median.