Fig. 4. The predicted probability of having screen-detected diabetes with elevated levels of both FPG and HbA1c.
a,b, The probability by sex, age and region of participants who did not have a previous diagnosis of diabetes of having elevated HbA1c (≥6.5%) at different FPG and BMI levels (a) and elevated FPG (≥7.0 mmol l−1) at different HbA1c and BMI levels (b). The probabilities were calculated using coefficients of prediction equation model 8, with measurement method set to laboratory for prediction. These results show the probability that the second biomarker, had it been measured, would be above the clinical threshold for diabetes diagnosis, for a person whose first biomarker was above the clinical threshold for diabetes diagnosis. Having elevated levels of both biomarkers has high positive predictive value for subsequent clinical diagnosis and risk of complications14,47.