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. 2023 Jul 14;33(12):8889–8898. doi: 10.1007/s00330-023-09920-6

Fig. 3.

Fig. 3

Schematic overview of the study workflow and statistical analysis. From a total cohort of 509 patients from 9 centers, 412 patients (from 6 centers) were used to develop a prediction model to predict two respective outcomes (complete response, good response) using repeated hold-out validation. For both outcomes, the best-performing model was tested on an external and independent validation cohort consisting of 97 patients (from 3 different centers)