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. 2023 Nov 23;13:20612. doi: 10.1038/s41598-023-46841-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Subnetworks derived from the complete cancer-relevant network in Fig. 4. These networks represent the first 4 key pathways involved in cancer pathogenesis according to the presented PPI networking in Fig. 4. The thickness of the lines (i.e., edges) represents the degree of confidence (i.e., the strength of data support). Nodes encircled with red line in the PI3K-Akt signaling pathway cluster are CDK6 and HRAS that were predicted to be potential targets for compound 3.