Table 3.

Operational criteria/definition for global or regional disease-specific eradication, elimination and control of NTDs under the Regional Flagship Priority in the South-East Asia Region.

Disease	Geographical scope	Operational criteria/definition
Eradication
Yaws	Global	Absence of a new, infectious, serologically confirmed indigenous yaws cases for three consecutive years, supported by high coverage of active surveillance.21
Elimination (interruption of transmission)
Leprosy	Global	There is no more local transmission of M. leprae, evidenced by zero new autochthonous cases among children (less than 15 years old) for at least five years.22
Elimination as a public health problem
Kala-azar	Regional	i) Annual incidence of kala-azar at the district or sub-district level in all endemic countries in the SE Asia Region: less than one per 10,000 population; and ii) Case-fatality rate due to primary visceral leishmaniasis (VL): less than 1%.14
Lymphatic filariasis	Global	Prevalence of infection with Wuchereria bancrofti, Brugia malayi or Brugia timori less than target thresholds in all endemic areas.23
Trachoma	Global	Reduction in the prevalence of trachomatous trichiasis “unknown to the health system” to less than 0.2% in adults aged 15 years and older; a reduction in the prevalence of the active trachoma sign “trachomatous inflammation-follicular” (TF) in children aged 1–9 years to less than 5% (sustained for at least two years in the absence of intervening antibiotic mass drug administration); and the presence of a system to detect and manage incident cases of trachomatous trichiasis, with evidence of appropriate support for that system.24